Overview of Arava (Leflunomide)

What is Arava?​

The active substance in Arava, leflunomide, is an immunosuppressant.​ It reduces inflammation by reducing the production of immune cells called lymphocytes, which are responsible for inflammation.​ Leflunomide does this by blocking an enzyme called dihydroorotate dehydrogenase, which is necessary for the lymphocytes to multiply.​ Arava is a prescription drug approved by the FDA to treat active rheumatoid arthritis in adults.​ It is sometimes also prescribed off-label to treat lupus.​ If you have questions about the medication, consult your healthcare provider or pharmacist to understand if it is suitable for your condition.​

How does Arava work?​

Arava, containing the active substance leflunomide, works by suppressing inflammation in the body. Leflunomide blocks an enzyme called dihydroorotate dehydrogenase, which is crucial for the production of immune cells that contribute to inflammation. By reducing the multiplication of these immune cells, Arava helps alleviate inflammation associated with conditions like rheumatoid arthritis.​ It falls under the class of medications known as disease-modifying antirheumatic drugs (DMARDs), which aim to reduce inflammation and halt disease progression.​ If you have further questions about how Arava works or its effects on your condition, consult your healthcare provider for personalized advice.

Uses and Benefits

Arava, containing the active ingredient leflunomide, is primarily used in the treatment of rheumatoid arthritis in adults.​ It is classified as a disease-modifying antirheumatic drug (DMARD) and works to reduce inflammation and prevent further joint damage caused by this autoimmune condition.​ Arava is prescribed by healthcare providers to alleviate the symptoms of moderate to severe rheumatoid arthritis and, in some cases, lupus.​ It is important to follow your healthcare provider’s instructions carefully when taking Arava to ensure optimal benefits and manage any potential side effects effectively.

Approved Treatments

Arava, also known as leflunomide, is an FDA-approved medication used to treat active rheumatoid arthritis in adults.​ It falls under the category of disease-modifying antirheumatic drugs (DMARDs) and is prescribed to help reduce inflammation and prevent further joint damage caused by rheumatic conditions. It is critical to follow your healthcare provider’s guidance when using Arava to ensure safe and effective treatment.

Off-label Uses

Arava, known as leflunomide, is primarily used for the treatment of active rheumatoid arthritis in adults.​ However, healthcare providers may prescribe it off-label for conditions like lupus when other treatment options have not been effective or tolerated well.​ It is essential to consult with your healthcare provider before using Arava for any condition other than those approved by the FDA to ensure its safety and effectiveness for your specific case.​

Dosage and Administration

When it comes to taking Arava (Leflunomide) for the treatment of rheumatoid arthritis or other conditions, your healthcare provider will determine the appropriate dosage for your specific case.​ Typically, the starting dose of Arava is a loading dose of 100 mg orally once a day for 3 days٫ followed by a maintenance dose of 20 mg orally once a day.​ However٫ adjustments may be made based on individual response and tolerability.​ It is crucial to adhere to your doctor’s instructions regarding dosage and administration to optimize the benefits of Arava and minimize the risk of side effects.​

Recommended Dosage

For the treatment of rheumatoid arthritis, the recommended dosage of Arava (leflunomide) typically starts with a loading dose of 100 mg orally once a day for 3 days٫ followed by a maintenance dose of 20 mg orally once a day.​ Your healthcare provider will determine the most suitable dosage based on your individual condition and response to the medication.​ It is essential to strictly follow the prescribed dosage regimen to achieve the desired therapeutic effects while minimizing potential risks.​ If you have any concerns about the dosage or administration of Arava٫ consult your healthcare provider for personalized guidance.​

Administration Instructions

When taking Arava (leflunomide) for the treatment of rheumatoid arthritis or other rheumatic conditions, it is important to follow your healthcare provider’s administration instructions diligently.​ Typically, Arava is taken orally once a day, with tablets available in 10 or 20 mg doses.​ It is crucial to take the medication as prescribed by your healthcare provider, ensuring consistent daily intake to achieve optimal therapeutic effects.​ If you have any concerns or questions regarding the administration of Arava, do not hesitate to consult your healthcare provider for guidance.​

Side Effects and Warnings

When taking Arava (leflunomide), it is important to be aware of potential side effects and warnings associated with the medication.​ Some common side effects may include gastrointestinal disturbances, skin reactions, and hair loss.​ It is crucial to contact your healthcare provider if you experience any severe side effects such as liver problems, difficulty breathing, unusual bleeding, numbness, tingling, or severe skin reactions.​ Additionally, it is essential to follow the prescribed dosage regimen and undergo regular monitoring to ensure the safe use of Arava and minimize potential risks.​

Common side effects of Arava (leflunomide) may include gastrointestinal disturbances, such as nausea and diarrhea, skin reactions like rash, and hair loss.​ These side effects are typically mild and may improve as your body adjusts to the medication.​ If these common side effects persist or worsen, it is important to inform your healthcare provider.​ Additionally, contact your doctor promptly if you experience any severe or concerning side effects while taking Arava.​

Severe Side Effects

While taking Arava (leflunomide), it is crucial to be vigilant for any severe side effects that may indicate a serious reaction to the medication.​ If you experience symptoms such as severe liver problems (e.​g., nausea, upper stomach pain, fatigue, loss of appetite, jaundice), respiratory issues (e.g.​, chest pain, wheezing, shortness of breath), unusual bleeding or bruising, numbness, tingling, or severe skin reactions (e.​g.​, blistering, peeling rash), seek immediate medical attention.​ These severe side effects require prompt evaluation and medical intervention to ensure your well-being.​

Warnings and Precautions

Before taking Arava (leflunomide) for the treatment of rheumatoid arthritis or other rheumatic conditions, it is essential to be aware of certain warnings and precautions associated with the medication.​ Arava can potentially cause severe or fatal liver damage, making it crucial to inform your healthcare provider about any history of liver disease or use of specific medications.​ Additionally, if you suspect you might be pregnant, it is important to stop taking Arava and undergo a drug elimination procedure to reduce the risk to the developing fetus. Always communicate openly with your healthcare provider about your medical history and any concerns to ensure safe and effective treatment with Arava.​

Common side effects of Arava (leflunomide) may include gastrointestinal disturbances like nausea and diarrhea, skin reactions such as rash, and hair loss.​ These common side effects are typically mild and may improve as your body adjusts to the medication.​ However, if these side effects persist or become bothersome, it is recommended to consult your healthcare provider for further guidance.

Who should not use Arava?​

Arava (leflunomide) is not suitable for individuals who are pregnant, as it can potentially harm the developing fetus.​ It is important to have a negative pregnancy test before starting Arava treatment and to use effective contraception during the course of treatment.​ Additionally, individuals with a history of severe liver disease or certain infections should avoid using Arava.​ If you have any concerns about whether Arava is safe for you, discuss your medical history with your healthcare provider for personalized advice.​

Common Side Effects

Common side effects of Arava (leflunomide) may include gastrointestinal disturbances like nausea and diarrhea, skin reactions such as rash, and hair loss.​ These common side effects are typically mild and may improve as your body adjusts to the medication.​ However, if these side effects persist or become bothersome, it is recommended to consult your healthcare provider for further guidance.​

When taking Arava (leflunomide), it is essential to be aware of potential drug interactions that can affect the medication’s effectiveness or increase the risk of side effects. Interactions may occur when Arava is used concomitantly with hepatotoxic or hematotoxic drugs, leading to increased side effects or adverse reactions. It is crucial to inform your healthcare provider about all medications, supplements, or herbal products you are taking before starting Arava to prevent any harmful interactions. Your doctor can provide guidance on managing potential drug interactions while using Arava.​

Drug Interactions

When taking Arava, it is important to be cautious about potential drug interactions that may affect the efficacy or safety of the medication.​ Interactions can occur when Arava is combined with hepatotoxic or hematotoxic drugs, leading to an increased risk of side effects or adverse reactions.​ It is crucial to inform your healthcare provider about all medications, including over-the-counter drugs, supplements, and herbal products, that you are taking while using Arava to prevent any harmful interactions and ensure the effectiveness of your treatment.​

Food Interactions

When taking Arava (leflunomide), it is essential to be mindful of potential food interactions that may impact the absorption or effectiveness of the medication.​ Some foods, such as grapefruit, could interact with Arava and either increase or decrease its blood levels, leading to potential side effects or reduced efficacy.​ It is advisable to consult your healthcare provider or pharmacist for guidance on managing food interactions while using Arava to ensure optimal treatment outcomes.

Pregnancy and Lactation

It is crucial to avoid the use of Arava if you are pregnant, as the medication can potentially harm the developing fetus. If there is a possibility of pregnancy or if you suspect you might be pregnant while taking Arava, it is recommended to stop the medication immediately.​ Effective contraception is necessary during Arava treatment and until a drug elimination procedure is completed to eliminate the drug from your system.​ It is essential to discuss pregnancy and breastfeeding considerations with your healthcare provider before starting Arava to ensure the safety of both mother and baby.​

Use in Pediatric Patients

The use of Arava (leflunomide) in pediatric patients is not well established, and the safety and efficacy of this medication in children have not been adequately studied.​ It is essential to consult with a pediatric rheumatologist or a healthcare provider experienced in treating pediatric rheumatic conditions before considering the use of Arava in children.​ The potential risks and benefits of using Arava in pediatric patients should be carefully evaluated to ensure appropriate treatment and minimize any associated risks.​

Use in Geriatric Patients

When considering the use of Arava (leflunomide) in geriatric patients, certain precautions and considerations should be taken into account due to age-related changes in health and medication tolerance.​ Geriatric patients may be more susceptible to the side effects of Arava, such as liver problems or infections.​ It is essential for healthcare providers to assess the individual patient’s health status, comorbidities, and medication regimen to determine the most appropriate treatment plan while ensuring the safety and well-being of geriatric patients.​

Storage and Handling

It is recommended to store Arava (leflunomide) at room temperature away from moisture, heat, and light.​ Make sure to keep the medication out of reach of children and pets. Do not store Arava in the bathroom or near the kitchen sink.​ Follow the storage instructions provided by your healthcare provider or pharmacist to ensure the stability and effectiveness of the medication.​

Proper Storage Instructions

To maintain the effectiveness and stability of Arava (leflunomide), it is crucial to store the medication appropriately.​ Keep Arava at room temperature, away from moisture, heat, and light.​ Store the tablets in a dry place and ensure they are out of reach of children and pets to prevent accidental ingestion. Avoid storing Arava in the bathroom or near areas prone to humidity.​ If you have any concerns about the storage of Arava, consult your healthcare provider or pharmacist for guidance.​

Disposal Information

Proper disposal of Arava (leflunomide) is essential to prevent accidental ingestion by children or pets and to minimize environmental impact.​ When discarding unused or expired medication, it is recommended to take it to a local pharmacy or healthcare provider for safe disposal.​ Do not dispose of Arava by flushing it down the toilet or throwing it in the trash, as this can pose risks to the environment and public health.​ By following appropriate disposal guidelines, you can contribute to ensuring the safe handling of medication.​

Additional Information

Arava (leflunomide) is a disease-modifying antirheumatic drug (DMARD) approved by the FDA primarily to treat active rheumatoid arthritis in adults.​ This medication belongs to a class of drugs known as pyrimidine synthesis inhibitors and works by reducing inflammation associated with autoimmune conditions. It is essential to follow your healthcare provider’s instructions carefully and attend regular monitoring appointments to ensure the safe and effective use of Arava for managing rheumatic diseases.

Manufacturer Details

Arava, marketed under the brand name Arava (leflunomide), is manufactured by sanofi-aventis Canada Inc.​ The company is located at 2905, Place Louis-R.​-Renaud, Laval, Quebec, H7V 0A3.​ For further information or inquiries about the manufacturing details of Arava, you can contact sanofi-aventis Canada Inc.​ at the provided address.​

Resources for Further Reading

For additional information on Arava (leflunomide), you may visit the official website of the manufacturer, sanofi-aventis Canada Inc.​ They provide detailed product information, medication guides, and resources that can help you understand more about Arava and its uses in the treatment of rheumatic conditions.​ Additionally, consulting reliable medical sources, such as the American College of Rheumatology, can offer valuable insights and resources on the safety and efficacy of Arava for managing rheumatoid arthritis.​