Adalat CC Extended-Release Tablet Description

Introduction

The Adalat CC Extended-Release Tablet is a dosage form of the calcium channel blocker nifedipine, indicated for the treatment of hypertension.​ Nifedipine is a yellow crystalline substance, practically insoluble in water.​ It is available in 30, 60, or 90 mg doses for once-a-day oral administration.​ This medication is used to lower high blood pressure and to treat chest pain. Its mechanism of action involves relaxing blood vessels, reducing the heart’s workload, and improving blood flow.​

Description of Adalat CC Extended-Release Tablet

The Adalat CC Extended-Release Tablet is a formulation of the calcium channel blocker nifedipine in an extended-release dosage form.​ Nifedipine, a yellow crystalline substance, is primarily insoluble in water but soluble in ethanol.​ This tablet is designed for once-a-day oral administration and is indicated for the treatment of hypertension and chest pain.​ Each tablet contains either 30, 60, or 90 mg of nifedipine and is composed of both a slow-release external coat and a fast-release internal core to achieve therapeutic efficacy.​

Structure and Composition

The Adalat CC Extended-Release Tablet consists of an external coat and an internal core.​ The tablet is formulated with the calcium channel blocker nifedipine, a yellow crystalline substance that is practically insoluble in water but soluble in ethanol.​ The external coat is designed for slow release, while the internal core provides fast release of nifedipine. Each tablet is available in 30, 60, or 90 mg doses for oral administration once a day to achieve the desired therapeutic effects.​

Indications and Dosage

Adalat CC Extended-Release Tablet is primarily indicated for the treatment of hypertension and chest pain. The tablet is available in doses of 30, 60, or 90 mg, designed for once-daily oral administration.​ The recommended dosage regimen involves taking the tablet on an empty stomach.​ Dosing adjustments should be made based on individual patient needs and responses to the medication. It is essential to follow the prescribed dosage and administration instructions provided by the healthcare provider to ensure optimal therapeutic outcomes.

Brand Names and Drug Class

The Adalat CC Extended-Release Tablet is also known by various brand names such as Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, and Procardia.​ It belongs to the drug class of calcium channel blocking agents.​ This medication comes in the form of extended-release tablets in doses of 30, 60, or 90 mg, providing convenient options for patients requiring treatment for hypertension and chest pain.​

Proper Administration

Adalat CC Extended-Release Tablets should be taken orally once daily on an empty stomach.​ The dosage of the tablet may need adjustments based on individual patient requirements.​ It is crucial to swallow the tablets whole without chewing, breaking, or crushing them.​ Switching to a different brand, strength, or form of the medication may necessitate changes in dosage.​ To prevent medication errors, always adhere strictly to the form and strength prescribed by the healthcare provider.​

Side Effects and Adverse Reactions

Common side effects of Adalat CC Extended-Release Tablet may include dizziness, headache, flushing, or swelling in the ankles or feet.​ Serious but rare side effects may include shortness of breath, fast or irregular heartbeat, or fainting.​ It is important to seek medical attention if you experience any severe adverse reactions while taking this medication.​ It is recommended to inform your healthcare provider of any side effects encountered during the course of treatment.

Special Warnings and Precautions

Special precautions should be observed when taking Adalat CC Extended-Release Tablet. Patients should be cautious while rising from a lying or sitting position due to potential dizziness associated with the medication.​ It is important to avoid consuming grapefruit or grapefruit juice while on this medication as it may interact and lead to adverse effects.​ Individuals with certain medical conditions should exercise caution, and dosage adjustments may be necessary based on individual responses;

Clinical Pharmacology

The Adalat CC Extended-Release Tablet constitutes an extended-release formulation of nifedipine, a calcium channel blocker.​ Nifedipine, a yellow crystalline substance insoluble in water, functions to relax blood vessels, decrease the heart’s workload, and enhance blood flow.​ This medication is indicated for the treatment of hypertension and chest pain, exerting its therapeutic effects through the modulation of calcium ion influx across cell membranes.​

Comparative Analysis with Other Nifedipine Formulations

When comparing Adalat CC Extended-Release Tablet with other nifedipine formulations like Procardia XL, the primary distinction lies in the mechanism of nifedipine release.​ While Procardia XL utilizes an osmotic pump delivery system for leaching nifedipine, Adalat CC sloughs off the calcium channel blocker through successively dissolving layers. Adalat CC is specifically indicated for the treatment of hypertension either alone or in combination with other antihypertensive agents.​ It is crucial to note that nifedipine must not be used in cases of cardiogenic shock or known hypersensitivity to the drug.​

Recent Developments and Approvals

Recently, Elan Corp of Ireland has received tentative US approval for a generic version of Bayer Corp’s Adalat CC, which comprises nifedipine extended-release tablets in a 30mg dosage.​ This development marks a significant milestone in providing more accessible medication options to patients.​ Additionally, further advancements and approvals in the field of extended-release formulations like Adalat CC are anticipated to enhance treatment options for individuals dealing with hypertension and chest pain.​

In conclusion, Adalat CC Extended-Release Tablet, formulated with the calcium channel blocker nifedipine, offers a reliable therapeutic option for individuals with hypertension and chest pain.​ The extended-release formulation of this medication provides convenience in dosing and efficacy.​ Recent approvals for generic versions of Adalat CC indicate a positive trend towards increased accessibility to essential medications for patients.​ With proper administration and adherence to dosage instructions, Adalat CC continues to be a valuable treatment option in managing cardiovascular conditions.​